Folklore Clinical Variant Interpretation

Connection contract

Use Streamable HTTP. Folklore does not require an account, API key or OAuth flow.

Endpoint

https://api.helena.bio/folklore/v1/mcp

Tools

search_variant_evidence, search_variant_literature, get_publication_details, search_literature_corpus

Workflow prompts

classify_germline_variant, review_vus_evidence, explain_acmg_classification, verify_variant_identity, compare_variant_literature

Authentication

None

Registry name

io.github.helena-bioinformatics/folklore

Direct client connections

Every client below reaches the same endpoint and tool. A tested custom connection means that Folklore was connected in that client. It does not mean the provider has approved a public directory listing.

ChatGPT

Tested custom app

Create a custom MCP app and use the Folklore endpoint. No authentication fields are required.

Claude

Tested custom connector

Add a custom connector with the Folklore endpoint. The connection does not require an account or API key.

Codex and Cursor

Direct HTTP configuration

Add a server named folklore with the url field shown below.

VS Code

Direct HTTP configuration

Add a server named folklore with type http and the Folklore endpoint as its url.

Gemini CLI

Direct HTTP configuration

Add a server named folklore in the Gemini CLI MCP settings, select HTTP transport and use the Folklore endpoint.

Perplexity, Grok and Windsurf

Remote connector configuration

Use the same endpoint in the client remote MCP or custom connector settings. Select Streamable HTTP when the client asks for a transport.

Codex and Cursor

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

VS Code

{
  "servers": {
    "folklore": {
      "type": "http",
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

Verified public listings

These pages were publicly reachable when this guide was reviewed on 25 August 2026. The Official MCP Registry is the canonical machine-readable publication source. Aggregator health labels do not replace the Folklore health and readiness checks.

Official MCP Registry

Canonical registry identity io.github.helena-bioinformatics/folklore. Version 1.4.1 is the current published release.

Active

Glama

The listing is owned by Helena Bioinformatics and uses the canonical Folklore endpoint.

Active and claimed

MCPBeat

Automatically discovered listing. Registry metadata can take time to refresh after a release.

Active

mcpservers.org

Editorially approved public listing. Its durable slug remains stable while the display-name update is processed.

Active

Submitted and under review

Submission is recorded separately from publication. The links below show the durable public review item where one exists. ChatGPT and Claude directory submissions are complete, but public directory approval has not been independently verified. Smithery publication is deferred.

Ask a bounded question

Example: Use Folklore to classify ENST00000226413.5:c.317A>G under ACMG/AMP and summarize the evidence, provenance and limitations.

Supported input includes GRCh38 coordinates, selected genomic, coding and protein HGVS, SPDI and rsID for one nuclear germline SNV or simple indel smaller than 50 base pairs. Ambiguous expressions return candidates for the user to choose.

For scientific literature questions, search_literature_corpus accepts natural language plus known PMID, DOI or PMCID anchors and returns source-linked candidates for professional review.

The separate support_helena tool is an explicit opt-in path to official Helena Good information. It does not initiate payment and cannot change any scientific result.

Clinical boundary

Folklore returns variant-level decision support for qualified genetics professionals. It accepts no patient, phenotype, family, segregation or case context. The automated classification is not a diagnosis, treatment recommendation or standalone clinical report.

A qualified professional must review the evidence and confirm clinically significant findings before clinical use.