Folklore Clinical Variant Interpretation

Gene-disease evidence for genomic analysis

Folklore is a bioinformatics MCP for the evidence and interpretation steps of human genomic analysis, including downstream WGS and WES workflows. It does not parse DNA sequences or VCF files, run variant calling, or accept batch or patient datasets.

Ask which genes have curated evidence for Marfan syndrome with search_disease_genes, or which diseases are associated with FBN1 using get_gene_disease_associations. Use the returned local source snapshot version and hash for reproducibility; this does not guarantee the latest ClinGen release. Initial source coverage is ClinGen gene-disease validity assertions. Preserve each relationship, inheritance mode, validity assessment, source report and evaluation date.

Gene-disease validity is separate from variant ACMG/AMP classification. Keep distinct disease matches separate; a missing record does not establish absence of an association.

Genomic analysis workflows and complete request examples

Connection contract

Use Streamable HTTP. Folklore does not require an account, API key or OAuth flow.

Endpoint

https://api.helena.bio/folklore/v1/mcp

Tools

search_variant_evidence, search_variant_literature, get_publication_details, search_literature_corpus, get_gene_disease_associations, search_disease_genes

Workflow prompts

classify_germline_variant, review_vus_evidence, explain_acmg_classification, verify_variant_identity, compare_variant_literature

Authentication

None

Registry name

io.github.helena-bioinformatics/folklore

Direct client connections

Every client below reaches the same endpoint and tool. A tested custom connection means that Folklore was connected in that client. It does not mean the provider has approved a public directory listing.

ChatGPT

Tested custom app

Create a custom MCP app and use the Folklore endpoint. No authentication fields are required.

Claude

Tested custom connector

Add a custom connector with the Folklore endpoint. The connection does not require an account or API key.

Codex and Cursor

Direct HTTP configuration

Add a server named folklore with the url field shown below.

VS Code

Direct HTTP configuration

Add a server named folklore with type http and the Folklore endpoint as its url.

Gemini CLI

Direct HTTP configuration

Add a server named folklore in the Gemini CLI MCP settings, select HTTP transport and use the Folklore endpoint.

Perplexity, Grok and Windsurf

Remote connector configuration

Use the same endpoint in the client remote MCP or custom connector settings. Select Streamable HTTP when the client asks for a transport.

Codex and Cursor

{
  "mcpServers": {
    "folklore": {
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

VS Code

{
  "servers": {
    "folklore": {
      "type": "http",
      "url": "https://api.helena.bio/folklore/v1/mcp"
    }
  }
}

Verified public listings

Selected entries from our shared public register, reviewed 2026-09-11. The Official MCP Registry is the canonical machine-readable publication source. Aggregator health labels do not replace the Folklore health and readiness checks.

Official MCP Registry

Version 1.5.0 is the current published release. Canonical Registry identity: io.github.helena-bioinformatics/folklore.

Public listing

Glama

Public presence checked 2026-09-11. See the full directory for all four Helena MCP servers.

Public listing

MCP Marketplace

Public presence checked 2026-09-11. See the full directory for all four Helena MCP servers.

Public listing

mcpservers.org

Public presence checked 2026-09-10. See the full directory for all four Helena MCP servers.

Public listing

See more

A direct client connection is separate from public provider-directory approval. The shared directory records verified public listings and their observation dates.

Ask a bounded question

Example: Use Folklore to classify ENST00000226413.5:c.317A>G under ACMG/AMP and summarize the evidence, provenance and limitations.

Supported input includes GRCh38 coordinates, selected genomic, coding and protein HGVS, SPDI and rsID for one nuclear germline SNV or simple indel smaller than 50 base pairs. Ambiguous expressions return candidates for the user to choose.

For scientific literature questions, search_literature_corpus accepts natural language plus known PMID, DOI or PMCID anchors and returns source-linked candidates for professional review.

The separate support_helena tool is an explicit opt-in path to official Helena Good information. It does not initiate payment and cannot change any scientific result.

Clinical boundary

Folklore returns variant-level decision support for qualified genetics professionals. It accepts no patient, phenotype, family, segregation or case context. The automated classification is not a diagnosis, treatment recommendation or standalone clinical report.

A qualified professional must review the evidence and confirm clinically significant findings before clinical use.

Connect your team with Folklore

Using Folklore in your laboratory or research team? Introduce your team if you would like help connecting your agents or a conversation about working together.

Optional. You can keep using the public MCP without introducing yourself or creating an account.

Introduce your team Continue with MCP setup